An Artificial Riboflavin Receptor Prepared by a Template Analogue Imprinting Strategy

Abstract

Cheers! Specificity for riboflavin in water-rich media with an affinity on the order found for the corresponding biological receptor, riboflavin binding protein, is shown by a receptor containing a complementary hydrogen bonding array (see picture). Microcalorimetry performed at low receptor concentrations in a solution mimicking an alcoholic beverage indicated the presence of a small but uniform population of high-affinity sites (K>106 M−1). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500342_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.