Rapid Formation of a Preoligomeric Peptide–Metal–Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

Abstract

CuII connects peptides: The mechanism of binding of CuII to amyloid β peptides (Aβ) implicated in Alzheimer's disease was elucidated by stopped-flow spectroscopy, NMR relaxation, and simulation of the kinetics on the millisecond timescale. Two monomeric Cu–Aβ species and a dimeric Aβ–Cu–Aβ species were identified (see picture). Aberrant aggregation apparently occurs from the monomeric species. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.