Synthesis of <i>N</i>‐Substituted‐2‐Aminobenzothiazoles by Ligand‐Free Copper(I)‐Catalyzed Cross‐Coupling Reaction of 2‐Haloanilines with Isothiocyanates

Abstract

Abstract A novel and efficient formation of N ‐substituted‐2‐aminobenzothiazoles by a ligand‐free copper(I)‐catalyzed one‐pot cascade process was developed. A variety of isothiocyanates coupled with 2‐iodoanilines to give N ‐substituted‐2‐aminobenzothiazoles in moderate to excellent yields under mild conditions. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)