Concepedia

Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

Anggakusuma, Inés Romero‐Brey, Carola Berger, Che C. Colpitts, Tujana Boldanova, Michael Engelmann, Daniel Tödt, Paula Monteiro Perin, Patrick Behrendt, Florian W. R. Vondran,

Hepatology · 2015 · 85 citations · 39 references

DOI

Abstract

Infection with HCV causes up-regulation of interferon-inducible CH25H in vivo, and its product, 25HC, restricts HCV primarily at the level of RNA replication by preventing formation of the viral replication factory.

References

39

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Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

Su-Yang Liu, Roghiyh Aliyari, Kelechi Chikere et al. · Immunity · 2012 · 660 citations · Full text

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Inés Romero‐Brey, Andreas Merz, Abhilash I. Chiramel et al. · PLoS Pathogens · 2012 · 508 citations · Full text

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