Agricultural and Biological Chemistry · 1977 · 18 citations · 3 references
Life SciencesBiochemistryMicrobiologyMetabolismMicrobial MetabolismMycologyAntimetabolite TherapyEnzyme InhibitionFungal Natural Product BiosynthesisFungal Secondary MetabolitesMetabolite IdentificationMicrobial Natural Product BiosynthesisAcid-catalyzed HydrolysisAntimetabolite Mechanisms Of ActionAntimicrobial MetabolitesHydrolysisL-threonine FermentationMolecular Formula AssignmentMolecular Formula DeterminationNew Species Description
New antimetabolite N-1409, an antagonist of L-threonine was isolated from the fermentation broth of Streptomyces. Taxonornical study on the producing strain made it a new species and named Streptomyces plumbeus n. sp. Sakai et Park after its leaden color of matured aerial mycelium. N-1409 substance was isolated as colorless needles, mp 218_??_220°C. Its molecular formula C12H21N4O8P•3/2 H2O was determined by elementary analysis and alkali titration. On acid hydrolysis, L-alanine, L-aspartic acid and a new phosphorus containing amino acid were obtained.
3