Nano Letters · 2011 · 186 citations · 25 references
PharmacyBiomedical EngineeringBiotechnologyDrug DeliveryNanomaterialsNanoparticle Drug DeliveryCancer NanomedicineDrug EncapsulationLipid-based NanoparticlesNanomedicineNanoparticle SynthesisNucleic Acid DeliveryLipid NanomaterialsLipid Nanoparticle Delivery SystemsLipid NanoparticlesLipid-based Nanoparticle FormulationNanoparticlesNucleic Acid NanocomplexesPoly(lactic-co-glycolic Acid)Poly(lactic-co-glycolic Acid) Nanoparticles
Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle molding process called Particle Replication In Nonwetting Templates (PRINT). The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32-46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.
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A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
S. Moein Moghimi, Peter Symonds, J. Clifford Murray et al. · Molecular Therapy · 2005 · 1.1K citations · Full text
Pharmacy, Pharmacology, Toxicology +17
Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform
Liangfang Zhang, Juliana M. Chan, Frank Gu et al. · ACS Nano · 2008 · 1K citations