Pd‐PEPPSI‐IPent^Cl: A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents

Abstract

No migration? No problem! A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents. The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all.