Effects of Ca²⁺channel blockers on store-operated Ca²⁺channel currents of Kupffer cells after hepatic ischemia/reperfusion injury in rats

Abstract

SOC is the main channel for the influx of Ca(2+) during hepatic I/R injuries. Calcium channel blockers, 2-APB, SK and F96365, econazole and miconazole, have obviously protective effects on I/R injury, probably by inhibiting I(SOC) in Kupffer cells and preventing the activation of Kupffer cells.