PubMed · 2014 · 27 citations · 18 references
Life SciencesNeurobiologyNeuroscienceMetabolismMetabolomicsNeurochemistryBrain Energy MetabolismCerebral PhysiologyDiabetes MellitusMagnetic Resonance SpectroscopyNeuronal MetabolismNuclear Magnetic Resonance Metabolomics1D Proton Nuclear Magnetic Resonance SpectroscopyCognitive Impairment AssociationsDiabetes-related Cognitive DeclineHypoxiaMagnetic ResonanceMetabolic Brain ImagingNuclear Magnetic Resonance SpectroscopyNuclear Magnetic Resonance Spectroscopy-based Metabolite Profiling
H-MRS) of the brain provides detailed information about the structure, dynamics, reaction state and chemical environment of molecules. It also measures the levels of brain metabolites such as myo-inositol (mI), N acetyl aspartate (NAA), creatine (Cr), choline (Cho), glutamate (Glu), glutamine (Gln) and gamma amino butyric acid (GABA). Several studies suggest that people with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive impairment in comparison with the general population. The altered metabolites may cause cognitive dysfunction in T2DM. This review article concludes that in T2DM, metabolite levels were altered in different regions of brain.
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