Possible Influence of Variant of the P-Glycoprotein Gene ( <i>MDR1/ABCB1</i> ) on Clinical Response to Guanfacine in Children with Pervasive Developmental Disorders and Hyperactivity

Abstract

Gene variants in MDR1 may influence guanfacine response on hyperactive-impulsive behaviors via altered membrane transport. If replicated in larger samples, additional studies would be important to clarify the mechanisms underlying this effect and to determine its clinical significance. 2.