A Heteroditopic Fluoroionophoric Platform for Constructing Fluorescent Probes with Large Dynamic Ranges for Zinc Ions

Abstract

A heteroditopic fluoroionophoric platform has been designed for constructing fluorescent probes for zinc ions over large concentration ranges. The responses of the prototype probes 3a and 3b to zinc ions were shown to be consistent with our hypothesis, according to which the modulation of photoinduced electron transfer followed by conformation rigidification or enhanced internal charge transfer of a ditopic ligand upon successive zinc coordination affords a sensitive fluorescence enhancement in one wavelength channel followed by an emission band shift to another wavelength channel. The heteroditopic arylvinyl-bipy platform established in this study provides a lead structure for constructing fluorescent probes for real-time live cell imaging of zinc ions over broad dynamic ranges.