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A Caveolae-Targeted L-Type Ca <sup>2+</sup> Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Cardiac Contractility

DOIFull Paper Access

113

Citations

15

References

2012

Year

Catherine A. Makarewich, Robert N. Correll, Hui Gao, Hongyu Zhang, Baohua Yang, Remus M. Berretta, Victor Rizzo, Jeffery D. Molkentin, Steven R. Houser
Circulation Research

Abstract

We provide proof of concept that Ca(2+) influx through LTCCs within caveolae signaling domains can activate "hypertrophic" signaling, and this Ca(2+) influx can be selectively blocked without reducing cardiac contractility.

References

YearCitations

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