Biaryl Axis as a Stereochemical Relay for the Enantioselective Synthesis of Antimicrotubule Agents

Abstract

Return to sender: A biaryl configuration that is controlled by a benzylic stereocenter in an atropo-selective Suzuki coupling in turn controls the stereocenter configuration in an SN1-type dehydrative cyclization performed at low temperature. Promising antimicrotubule biaryls of high optical purity are obtained in this manner. TFA=trifluoroacetic acid, pin=pinacolato. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600451_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.