One‐Step Synthesis of the Benzocyclo[penta‐ to octa‐]isoindole Core

Abstract

Three in one go: Unactivated dienes containing a cycloalkenyl moiety reacted with a range of substituted aryl halides in the presence of Pd(OAc)2/PPh3 to afford fused polycyclic heterocycles (see scheme). Three carbon–carbon bonds are formed in this domino reaction, which involves highly regioselective CC coupling and CH functionalization steps. DMF=N,N-dimethylformamide; Bn=benzyl, Ts=p-toluenesulfonyl. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.