Visible‐Light‐Induced Radical Tandem Aryldifluoroacetylation of Cinnamamides: Access to Difluoroacetylated Quinolone‐2‐ones And 1‐Azaspiro[4.5]decanes

Abstract

Abstract A visible light‐mediated difluoroacetylation of cinnamamides with ethyl bromodifluoroacetate as a CF 2 radical precursor is described. The reaction incorporates tandem cyclization or cyclization/dearomatization processes. The latter process occurs when there is a p ‐RO substituent on the aniline. This protocol affords straightforward new routes to separately synthesize quinoline‐2‐ones and spiro[4.5]decanes in moderate to good yields. magnified image