Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia

Abstract

Acute atorvastatin provides global cerebral protection, but only at the higher dose of 20 mg·kg(-1) ·day(-1) ; this was associated with a reduction in inflammation in both vascular and parenchymal compartments. Our results suggest that atorvastatin could also be beneficial when administered early after stroke.