Cyclooxygenase-2–Dependent Prostacyclin Formation and Blood Pressure Homeostasis

Abstract

These studies suggest that dysregulated expression of the COX-2 dependent, PGI(2) biosynthesis/response pathway in the renal inner renal medulla undermines the homeostatic response to a HSD. Inhibition of this pathway may contribute directly to the hypertensive response to NSAIDs.