Journal of Ect · 2001 · 90 citations · 22 references
MedicineNeurologyPharmacotherapyEpilepsyEpileptologyNeuropharmacologySeizure DisordersSeizure ManagementStatus EpilepticusAnticonvulsant DrugsElectrode Array PlacementGeneralized SeizuresRefractory Epilepsy TreatmentSeizuresStatus Epilepticus TreatmentTreatment-resistant EpilepsyTreatment-resistant Seizures
INTRODUCTION: Owing to its potent anticonvulsant actions, electroconvulsive therapy (ECT) has been proposed as an intervention for treatment-resistant seizure disorders. METHOD: We review the literature on the use of ECT in treatment-resistant epilepsy and status epilepticus (SE) and present a case of a patient who was in nonconvulsive SE for 26 days and then treated with ECT after all standard pharmacological strategies were exhausted. Because of skull defects, a novel electrode placement was used. RESULTS: Owing to massively elevated seizure threshold attributable to concomitant anticonvulsant medications, extraordinarily high electrical dosage was needed for ECT to elicit generalized seizures. Status was terminated after three successful ECT-induced seizures. However, the long-term functional outcome of the patient was poor. DISCUSSION: The role of ECT in the treatment algorithm for SE is discussed.
22
The Anticonvulsant Hypothesis of the Mechanisms of Action of ECT
Harold A. Sackeïm · Journal of Ect · 1999 · 253 citations
Medicine, Neuroscience, Pharmacology +13
Electroconvulsive therapy for treatment of intractable seizures
David A. Griesemer, Charles H. Kellner, Mark D. Beale · Neurology · 1997 · 99 citations
Medicine, Neurology, Pediatrics +13