Convergent and Rapid Assembly of Substituted 2-Pyridones through Formation of <i>N</i>-Alkenyl Alkynylamides Followed by Gold-Catalyzed Cycloisomerization

Abstract

A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh 3-catalyzed cycloisomerization.