<i>IDH1</i>and<i>IDH2</i>Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With<i>NPM1</i>Mutation Without<i>FLT3</i>Internal Tandem Duplication - Concepedia

Concepedia

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<i>IDH1</i>and<i>IDH2</i>Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With<i>NPM1</i>Mutation Without<i>FLT3</i>Internal Tandem Duplication

784

Citations

35

References

2010

Year

Peter Paschka, Richard F. Schlenk, Verena I. Gaidzik, Marianne Habdank, Jan Krönke, Lars Bullinger, Daniela Späth, Sabine Käyser, Manuela Zucknick, Katharina S. Götze,

Journal of Clinical Oncology

Abstract

IDH1 and IDH2 mutations are recurring genetic changes in AML. They constitute a poor prognostic factor in CN-AML with mutated NPM1 without FLT3-ITD, which allows refined risk stratification of this AML subset.

References

	Year	Citations

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