Biology of Blood and Marrow Transplantation · 2007 · 31 citations · 22 references
Life SciencesBiomedical EngineeringCell BiologyCell DifferentiationRegenerative MedicineStem Cell BiologyBone Tissue EngineeringMesenchymal DifferentiationMesenchymal Stem Cell TherapyStem Cell DifferentiationStem Cell PhysiologyTissue Engineering With Stem CellsBone Marrow Mesenchymal Stem CellsBone Marrow-derived Mesenchymal Stromal CellsDifferentiation CapacityMesenchymal Stromal Cell CultureMesenchymal Stromal Cell DifferentiationMesenchymal Stromal Cell IsolationStem Cell Proliferative PotentialTissue Explant Culture
Mesenchymal stromal cells (MSCs) are the spindle-shaped plastic-adherent cells isolated from BM, adipose, and other tissue sources, with multipotent differentiation capacity in vitro. However, whether MSCs truly qualify as stem cells is an area of some debate [1]. MSCs were first described by Friendenstein et al [2,3] as hematopoietic supportive cells of BM. They showed that MSCs could differentiate to bone in vitro and a subset of the cells had a high proliferative potential (CFU-F) when plated at low density in tissue culture [2,3].
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck et al. · Science · 1999 · 21.1K citations
Arnold I. Caplan · Journal of Orthopaedic Research® · 1991 · 6.5K citations