Concise Synthesis of the Antidepressive Drug Candidate GSK1360707 by a Highly Enantioselective Gold‐Catalyzed Enyne Cycloisomerization Reaction

Abstract

Out of depression: Indeed, no depressing results are obtained from a gold-catalyzed enyne cycloisomerization controlled by phosphoramidite ligands with TADDOL-related but acyclic backbones (see scheme; Cbz=benzyloxycarbonyl). The “triple-reuptake inhibitor” GSK1360707 was obtained in excellent yield and optical purity, therefore highlighting the relevance of asymmetric gold catalysis for practical applications. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.