Thyroid “Atypia of undetermined significance” with nuclear atypia has high rates of malignancy and BRAF mutation

Abstract

The AUS-NA subcategory was associated with the highest risk of malignancy and the greatest frequency of BRAF V600E (substitution of valine to glutamic acid at position 600) mutation. These findings suggest that subcategorization of AUS by cytomorphology and BRAF V600E mutation status is important for predicting the risk of malignancy.