Cp*Co^III‐Catalyzed C2‐Selective Addition of Indoles to Imines

Abstract

Overriding innate reactivity: The utility of a CoIII catalyst to promote the C2-selective addition of indoles to imines was demonstrated. The CoIII catalyst completely changed the regioselectivity in comparison with simple Lewis acid catalyzed Friedel–Crafts C3-selective addition. High turnover number (TON) of the catalyst, up to 1.8×102 (with s/c=200; see scheme; s/c is the substrate/catalyst ratio), was achieved. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.