Advanced Materials · 2008 · 1.1K citations · 21 references
PharmacyBiophysicsPharmaceuticsDrug DeliveryEndocytosisNanotechnologyCell-nanoparticle InteractionsCellular UptakeNanomaterials For Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle DesignCellular Trafficking Of NanoparticlesEndocytosis Of NanoparticlesNanoparticle Cellular UptakeNanoparticle DeliveryNanoparticle Drug Delivery SystemsNanoparticle Internalization MechanismsSize-dependent UptakeThermodynamic Analysis
The cellular uptake of nanoparticles by living cells is predicted to be strongly size-dependent, according the thermodynamic analysis, and an optimal particle radius of ∼ 25–30 nm at which the cellular uptake reaches a maximum of several thousand is shown to exist. The theoretical prediction provides valuable guidance for the rational design of nanoparticle-based drug-delivery systems.
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