Effect of Antidepressant Medication on Morning and Evening Thyroid Function Tests During a Major Depressive Episode

Abstract

The results suggest that (1) changes in thyroid function are related to clinical recovery rather than to a direct effect of the antidepressant drug and (2) patients with the lowest pretreatment evening thyrotropin secretion have the lowest rate of antidepressant response, and this may contribute to treatment resistance.