Effects of Chronic Administration of Amitriptyline, Gabapentin and Minocycline on Spinal Brain-Derived Neurotrophic Factor Expression and Neuropathic Pain Behavior in a Rat Chronic Constriction Injury Model

Abstract

Minocycline and amitriptyline both reduce NP behavior in a sciatic CCI rat model, but only minocycline reduces spinal BDNF, indicating different modes of action of these 2 drugs. The observed actions of minocycline closely fit the clinical needs for the treatment of NP.