Can <i>APC</i> mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families

Abstract

As age at manifestation and course of the disease may be rather variable, even in carriers of identical germline mutations, therapeutic decisions should be based on colonoscopic findings in individual patients rather than on the site of mutation. However, in patients with mutations within codons 1445-1580, it may be advisable to postpone elective colectomy because desmoids may arise through surgical intervention.