Enantioselective Friedel−Crafts Alkylation of Indoles with Nitroalkenes Catalyzed by Bifunctional Tridentate Bis(oxazoline)−Zn(II) Complex

Abstract

[reaction: see text] A more practical and efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes using bifunctional tridentate bis(oxazoline)-Zn(OTf)(2) as catalyst has been developed. Various types of the nitroalkylated indoles were obtained in excellent yields (85-99%) and high enantioselectivities (up to 98% ee).