Identification of a 17β‐Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer’s Disease and Prostate Cancer

Abstract

Ten out of ten! Androsterone derivatives inhibit 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), a versatile mitochondrial NAD+-dependent enzyme with potential roles in both Alzheimer's disease and prostate cancer. These androsterone derivatives could be useful tool compounds to help elucidate the role of 17β-HSD10 in these important diseases. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.