Oxindole Synthesis by Direct Coupling of CH and CH Centers

Abstract

An sp(2)/sp(3) get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl C(sp(2))-H and a C(sp(3))-H center (see scheme; DMF = N,N-dimethylformamide).