The First Total Synthesis of Efrapeptin C

Abstract

Synthetically challenging, the efrapeptins are a class of peptide antibiotics rich in α,α-dialkylated amino acids. Efrapeptin C (see picture) was synthesized for the first time by a combination of solution-phase and solid-phase peptide synthesis steps with segment condensations. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z19491_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.