Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysts

Abstract

Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod=1,5-cyclooctadiene, DCE=1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH2, OH, Br, F, and SiMe3 groups remain intact during the reaction. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.