The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.

Abstract

A B S T R A C T Sequential determinations of glucose out- flow and inflow, and rates of gluconeogenesis from ala- nine, before, during and after insulin-induced hypogly- cemia were obtained in relation to alterations in circu- lating epinephrine, norepinephrine, glucagon, cortisol, and growth hormone in six normal subjects. Insulin de- creased the mean (+SEM) plasma glucose from 89+3 to 39+2 mg/dl 25 min after injection, but this decline ceased despite serum insulin levels of 15322 gtU/ml.