Impacts of Hyper-Homocysteinemia and White Matter Hyper-Intensity in Alzheimers Disease Patients with Normal Creatinine: An MRI-Based Study with Longitudinal Follow-up - Concepedia

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Impacts of Hyper-Homocysteinemia and White Matter Hyper-Intensity in Alzheimers Disease Patients with Normal Creatinine: An MRI-Based Study with Longitudinal Follow-up

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2010

Year

Chi‐Wei Huang, Wen‐Neng Chang, Chun‐Chung Lui, C. F. Chen, Cheng‐Hsien Lu, Y. L. Wang, C. Chen, Yu-Ting Juang, Yu-Ting Lin, Manghui Tu,

Current Alzheimer Research

Abstract

tHcy is an independent risk factor for developing moderate to severe DWMHs in AD but shows non-significant effect on cognitive performance. The close association between high WMH score and poor initial MMSE suggests an additive impact in AD. The long-term effect of elevated tHcy on cognitive decline was not conclusive in the two-year follow-up period.