Dual Hydrogen‐Bond/Enamine Catalysis Enables a Direct Enantioselective Three‐Component Domino Reaction

Abstract

It takes two to tango: A dual catalyst system, composed of a highly enantioselective enamine catalyst and a multiple-hydrogen-bond catalyst, enabled the chemoselective union of two aldehydes and a nitromethane unit with near-perfect enantioselectivities, excellent diastereoselectivities, and high yields under neutral conditions (see scheme).