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DMSO‐Mediated Ligand Dissociation: Renaissance for Biological Activity of <i>N</i>‐Heterocyclic‐[Ru(η<sup>6</sup>‐arene)Cl<sub>2</sub>] Drug Candidates
164
Citations
22
References
2013
Year
Ligand Exchange ReactionChemistryHeterocycle ChemistryChemical BiologyPharmaceutical ChemistryInorganic CompoundMolecular PharmacologyBiological ScreeningBiological ActivityInorganic ChemistryStock SolutionsBiochemistryMechanism Of ActionLigand DissociationPharmacologyInorganic SynthesisMolecular DockingNatural SciencesCoordination ComplexMolecular ComplexMedicineDrug Discovery
Slipped under the radar? 1H NMR spectroscopic examination revealed that [Ru(η6-arene)Cl2(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.
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