Journal of Chemotherapy · 2007 · 11 citations · 2 references
PharmacyClinical PharmacokineticsPharmacokineticsNeonatologyPharmacokinetic VariabilityTherapeutic Drug MonitoringNeonatal Drug TherapyNeonatal MedicineNeonatal PharmacologyNeonatal PharmacotherapyPediatric PharmacokineticsPediatric Therapeutic Drug MonitoringAminoglycoside Therapeutic Drug MonitoringAntibiotic Therapy In NeonatesDosing In Premature InfantsNeonatal Antimicrobial DosingNeonatal DosingNeonatal Therapeutic Drug MonitoringNeonate DosingPharmacokinetics In Neonates
A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used. AMG pharmacokinetics present a strong interindividual and intraindividual variability in neonates; in the premature neonate AMG clearance is reduced and the half-life is longer, leading to higher serum trough concentrations. Neonates may require therapeutic drug monitoring (TDM) and a "tailored" therapeutic regimen. The aim of this work is to present our personal experience wtih TDM of gentamicin in 68 newborns and to compare it with data available in the literature.
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