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Cytokine accumulations in CSF of multiple sclerosis patients
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1990
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IL‑1β and TNF are known to induce astrogliosis, demyelination, fever, fatigue, and sleep disturbances, suggesting they could underlie diverse MS symptoms. The study quantified IL‑1β, TNF, and IL‑6 in CSF from MS and other neurologic disease patients using specific radioimmunoassays. IL‑1β and TNF were detected more frequently in CSF from patients with active MS than in inactive MS or other neurologic diseases, IL‑6 was rarely detectable, and cytokine levels did not correlate with pleocytosis, implying a CNS source.
We identified the cytokines interleukin-1 beta (IL-1β), tumor necrosis factor (TNF), and interleukin-6 (IL-6) by specific radioimmunoassays in the CSF of patients with multiple sclerosis (MS) and other neurologic diseases (OND). There was a high incidence of detectable IL-1β in patients with active MS compared with inactive MS or OND patients. TNF was also more frequently present in active MS than in OND CSF. By contrast, most MS CSF did not contain detectable IL-6. There was no correlation between the degree of CSF pleocytosis and the level of individual cytokines, suggesting that cytokine accumulations may be derived from CNS, and not CSF, cells. As IL-1β: and TNF experimentally induce astrogliosis, demyelination, temperature elevation, lassitude, and sleep, and results raise the possibility that these cytokines may contribute to a variety of manifestations in MS and in other disease states.