CYCLOOXYGENASE-2 INHIBITION: A POTENTIAL MECHANISM FOR INCREASING THE EFFICACY OF BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY FOR BLADDER CANCER

Abstract

The inhibition of PGE2 synthesis by COX inhibition favored the production of IL-12 by BCG activated DC. This potentially will result in the generation of a T-helper type 1, polarized T-cell response that may improve the efficacy of BCG therapy.