Putative Transport Mechanism and Intracellular Fate of <i>Trans</i>-1-Amino-3-¹⁸F-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer

Abstract

ASCT2, which is a Na(+)-dependent amino acid transporter, and to a lesser extent Na(+)-independent transporters play a role in the uptake of (14)C-FACBC by DU145 cells. Among the Na(+)-independent transporters, system L transporters are also involved in the transport of (14)C-FACBC. Moreover, (14)C-FACBC is not incorporated into proteins in cells. These findings suggest a possible mechanism of anti-(18)F-FACBC PET for prostate cancer.