HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically ¹¹C-Labeled Sel-Tagged Affibody Molecule

Abstract

To our knowledge, the Sel-tagging technique is the first that enables site-specific (11)C-radiolabeling of proteins. Here we present the finding that, in a favorable combination between radionuclide half-life and in vivo pharmacokinetics of the Affibody molecules, (11)C-labeled Sel-tagged Z(HER2:342) can successfully be used for rapid and repeated PET studies of HER2 expression in tumors.