Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene‐Fused Pyrrole Derivatives

Abstract

Add a ring: A catalytic asymmetric [8+2] cycloaddition reaction of azaheptafulvenes with alkylidene malonates was developed. When employing catalytic amounts of a chiral N,N′-dioxide L–NiII complex, the reaction afforded functionalized cycloheptatriene-fused pyrrole derivatives in excellent yields (up to 99 %), diastereoselectivities (>95:5 d.r.), and enantioselectivities (91–97 % ee) under mild conditions. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.