Concepedia

Publication | Open Access

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

DOIFull Paper Access

163

Citations

45

References

2011

Year

Saj Parathath, Stephanie L. Mick, Jonathan E. Feig, Victor Joaquin, Lisa Grauer, David M. Habiel, Max Gassmann, Lawrence B. Gardner, Edward A. Fisher
Circulation Research

Abstract

Hypoxic regions are present in murine plaques. Hypoxic macrophages have increased sterol content due to the induction of sterol synthesis and the suppression of cholesterol efflux, effects that are in part mediated by HIF-1α.

References

YearCitations

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