Antimycobacterial Friedelane-terpenoid from the Root Bark of Terminalia avicennioides

Abstract

<i>Terminalia avicennioides</i> is used to treat tuberculosis in the folk medicine of the Nupes of North Central Nigeria. Activity guided fractionation of the extract resulted in the isolation of triterpenoid friedelin. The structure of the isolated compound was elucidated with the aid of spectral comparison of IR, UV, one and two dimensional NMR experiments values. To the best of our knowledge, this is the first time friedelin is reported from this plant. The <i>in vitro</i> antimycobacterial activity of the isolated compound (friedelin) was performed against <i>Bacillus Calmette Guerin</i> (BCG) with MIC value at 4.9 μg/mL.