BORIS Binding to the Promoters of Cancer Testis Antigens, <i>MAGEA2</i>, <i>MAGEA3</i>, and <i>MAGEA4</i>, Is Associated with Their Transcriptional Activation in Lung Cancer

Abstract

These data suggest that BORIS positively regulates these CTAs by binding and inducing a shift to a more open chromatin conformation with promoter demethylation for MAGEA3 or independent of promoter demethylation in case of MAGEA2 and MAGEA4 and may be a key effector involved in their derepression in lung cancer.