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A. Critical Evaluation of the Knorr Synthesis of Tpifluoromethylpyrroles and the Reactivity of Diethyl 4-Trifluoromethyl-2-Methylpyrrole-3, 5-Dicarboxylate.
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1984
Year
Inorganic ChemistryChemical EngineeringEngineeringLithium Aluminium Hydrideβ-Trifluoromethyl GroupFluorous SynthesisAbstract β-Trifluoromethyl PyrrolesOrganic ChemistryChemistryCritical EvaluationHeterocycle ChemistryDerivative (Chemistry)Synthetic ChemistryKnorr SynthesisBiomolecular Engineering
Abstract β-Trifluoromethyl pyrroles are readily obtained by the Knorr synthesis, but the procedure fails for the preparation of the the α-isomers. The β-trifluoromethyl group reacts with alkoxide anions and is reduced with lithium aluminium hydride.
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