Protein Splicing of SufB Is Crucial for the Functionality of the <i>Mycobacterium tuberculosis</i> SUF Machinery

Abstract

The SufBCD complex is an essential component of the SUF machinery of [Fe-S] cluster biogenesis in many organisms. We show here that in Mycobacterium tuberculosis the formation of this complex is dependent on the protein splicing of SufB, suggesting that this process is a potential new target for antituberculous drugs.