High-relaxivity MRI contrast agents prepared from miniemulsion polymerization using gadolinium(iii)-based metallosurfactants

Abstract

Miniemulsion polymerization with amphiphilic gadolinium(III) complexes as metallosurfactants was explored as a new technique for the synthesis of high relaxivity MRI contrast agents. Well-defined metallo-colloids with up to 240% enhancement in relaxivity over their small molecular counterparts were obtained.