Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring‐Closing Metathesis

Abstract

The vacuolar-type (H+)-adenosine triphosphatase inhibitor oximidine III and its enamide and epoxide stereoisomers have been synthesized enantioselectively. A relay ring-closing metathesis (RCM) strategy was employed to facilitate the macrocyclization of a well-defined substrate possessing two differentially functionalized RCM alkene partners (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460042_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.